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Association of body composition and lung function in children with cystic fibrosis
Author(s) -
Pedreira C.C.,
Robert R.G.D.,
Dalton V.,
Oliver M.R.,
Carlin J.B.,
Robinson P.,
Cameron F.J.
Publication year - 2005
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20162
Subject(s) - medicine , cystic fibrosis , spirometry , pulmonary function testing , body mass index , gastroenterology , lung volumes , lung , respiratory disease , restrictive lung disease , dual energy x ray absorptiometry , fat free mass , fat mass , bone mineral , asthma , osteoporosis
Survival in cystic fibrosis has improved significantly in the last 30 years, with major therapeutic goals of delaying the progressive loss of pulmonary function and maintaining normal growth. Dual‐energy X‐ray absorptiometry (DEXA) was performed in children with cystic fibrosis (CF) to assess both bone mineral density and body composition. We hypothesised that there would be an association between body composition and pulmonary function in children with CF. Fifty subjects with CF (28 males), mean age 12.7 years, participated in the study. Body composition was determined by DEXA. Body mass index (BMI) was calculated from the ratio of weight/height 2 (kg/m 2 ). Lung function was assessed by spirometry. Most patients (78%) had mild lung disease. The mean forced expired volume in 1 sec precent predicted (FEV 1 % predicted) for the 50 patients was 79.2% (range, 24–117%). There was a strong association between FEV 1 % predicted and BMI (R = 0.59, P = 0.0001). Fat‐free mass had positive association with pulmonary function tests (R = 0.30, P = 0.03). Although fat mass showed a positive correlation with pulmonary function, this association did not reach statistical significance. In our group of children with CF and mild lung disease, pulmonary function was more strongly associated with BMI than with fat and fat‐free mass. Pediatr Pulmonol. 2005; 39:276–280. © 2005 Wiley‐Liss, Inc.