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Exhaled nitric oxide is reduced in infants with rhinorrhea
Author(s) -
Franklin Peter J.,
Turner Stephen W.,
Hall Graham L.,
Moeller Alex,
Stick Stephen M.
Publication year - 2005
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20149
Subject(s) - rhinorrhea , medicine , wheeze , exhaled nitric oxide , respiratory system , pediatrics , anesthesia , surgery , asthma , bronchoconstriction
In infants, the effect of colds and other respiratory tract infections (RTI) on exhaled nitric oxide (FE NO ) is not clear. In this study, we measured FE NO in 24 infants (14 boys) who presented with rhinorrhea, with or without cough but not wheeze. Twelve of these infants had a history of recurrent wheeze. Levels were compared with a group of 23 healthy infants (13 boys). Further, 8 infants (5 with a history of recurrent wheeze) with rhinorrhea were tested after symptoms had resolved. Infants with rhinorrhea had significantly lower FE NO than the healthy infants (11.9 vs. 23.8 ppb, respectively, P < 0.0007). Levels increased from 7.5 ppb to 34.1 ppb in the 8 infants tested with and without symptoms ( P = 0.0002). Infants with rhinorrhea have reduced FE NO , irrespective of their respiratory history. © 2004 Wiley‐Liss, Inc.