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Passive smoking does not increase hydrogen peroxide (H 2 O 2 ) levels in exhaled breath condensate in 9‐year‐old healthy children
Author(s) -
Doniec Zbigniew,
Nowak Dariusz,
Tomalak Waldemar,
Pisiewicz Krzysztof,
Kurzawa Ryszard
Publication year - 2005
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.20129
Subject(s) - medicine , exhaled breath condensate , exhalation , passive smoking , tobacco smoke , vital capacity , spirometry , gastroenterology , anesthesia , lung function , lung , asthma , pathology , environmental health , diffusing capacity
Environmental tobacco smoke, also called passive smoking, was shown to have adverse effects on the health of children. Hydrogen peroxide (H 2 O 2 ) is proposed as a sensitive marker of oxidative injury and inflammatory processes in the airways, being increased in adult active cigarette smokers. We tested whether passive smoking had an influence on H 2 O 2 exhalation in healthy children. Thirty healthy passive smoking and 24 nonexposed healthy children aged 9 years were included in the study. Exhaled breath condensate (EBC) was obtained by spontaneous tidal volume breathing with EcoScreen (Jaeger, Germany). All subjects underwent flow‐volume measurements immediately after EBC collection. Levels of H 2 O 2 were measured fluorimetrically with the homovanillic acid method. Lung function did not differ between the passive smoking and nonexposed children groups. In the passive smoking group, EBC H 2 O 2 concentration (median and range) was 0.32 (0.00–1.20) μM, and did not differ significantly ( P > 0.05) from that found in the nonexposed group, i.e., 0,22 (0.00–0.68) μM. Exhaled H 2 O 2 did not correlate with spirometric parameters (FEV 1 , FEV 1 %FVC, and MEF50%FVC) in either group. We conclude that passive smoking does not increase H 2 O 2 exhalation in healthy children. © 2004 Wiley‐Liss, Inc. © 2004 Wiley‐Liss, Inc.