Premium
C‐reactive protein in acute pulmonary exacerbations of patients with cystic fibrosis
Author(s) -
Friesen Craig A.,
Wiens Lynn A.,
Burry V. Fred,
Portnoy Jay,
Roberts Charles C.
Publication year - 1995
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950200403
Subject(s) - medicine , cystic fibrosis , c reactive protein , pulmonary function testing , asthma , gastroenterology , antibiotics , respiratory disease , lung , inflammation , microbiology and biotechnology , biology
Abstract C‐reactive protein (CRP) concentrations were evaluated in 9 cystic fibrosis (CF) patients with acute pulmonary exacerbations and 14 patients with acute exacerbations of asthma without any symptoms of an acute infection. CRP concentrations were serially evaluated over the course of therapy in CF patients and compared with pulmonary function tests (PFTs) and clinical scores. CF patients were treated with aerosolized bronchodilators, intravenous fluids, and chest physiotherapy for 48 hours. Intravenous antibiotic therapy was added after 48 hours. Initial CRP concentrations differed significantly between patients with CF and those with asthma. CRP concentrations were elevated in 7 of 9 CF patients versus 3 of 14 asthma patients ( P < 0.02). In CF patients, CRP concentrations did not correlate with PFTs (except on day 0) or clinical scores. Frequently PFTs and clinical scores continued to improve after CRP levels had reached their lowest concentrations. CRP concentrations decreased only after the addition of antibiotic therapy. Pediatr Pulmonol. 1995; 20:215–219 . © 1995 Wiley‐Liss, Inc.