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Interrelationship between postocclusional oscillatory pressure transients and standard lung function in healthy and asthmatic children
Author(s) -
Frey Urs,
Kraemer Richard
Publication year - 1995
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950190612
Subject(s) - medicine , lung volumes , airway obstruction , airway resistance , pulmonary function testing , airway , cardiology , anesthesia , lung
We studied the correlation between characteristics of the postocclusional oscillatory airway opening pressure transients after flow interruption and body height, the degree of pulmonary hyperinflation [measured by thoracic gas volume (TGV)], and the degree of airway obstruction [measured by airway resistance (Raw)] and maximal expiratory flow at 50% vital capacity (MEF 50 ) in 10 healthy and 50 asthmatic children age 7–16 years. Focusing on the damped oscillatory change in pressure, the first derivative of the shutter cutve was analyzed, featuring natural frequency f 0 and damping factor d in the time domain, and frequency F FS and power A FS in the frequency domain. A maximal frequency was found at ∼80 Hz without two peak distribution as described in dogs. Multiple linear forward step analysis revealed that ω 0 , (the undamped, natural frequency) and A FS were related to body height ( P < 0.001). The damping factor d (independent of body height) was related to TGV and MEF 50 ( P < 0.001), and F FS to Raw ( P < 0.001). The analysis of the postocclusional pressure transients after airflow interruption provides information on the resistive, elastic and inertive properties of the thoraco‐pulmonary system. The measurements obtained are influenced by the end‐expiratory resting level (or the degree of pulmonary hyperinflation) and the degree of airway obstruction. © 1995 Wiley‐Liss, Inc.