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Comparison of airway reactivity induced by cold air and methacholine challenges in asthmatic children
Author(s) -
de Benedictis Fernando M.,
Canny Gerard J.,
MacLusky Ian B.,
Levison Henry
Publication year - 1995
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950190603
Subject(s) - methacholine , medicine , hyperventilation , asthma , bronchial hyperreactivity , anesthesia , airway , provocation test , respiratory disease , lung , alternative medicine , pathology
Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV 1 from baseline at 4 min. after the challenge (Δ% FEV 1 CAH), and the response to methacholine as the provocative concentration required to reduce the FEV 1 by 20% from baseline (PC 20 MCH). Both tests were sensitive (94%) for detecting airway hyperreactivity. There was no statistically significant relationship between A% FEV, CAH and the log PC 20 MCH ( r = 0.39; P = 0.12). In clinical practice, methacholine test is easier to perform, but in the research field cold air challenge may be preferable because it avoids potential drug effects. © 1995 Wiley‐Liss, Inc.