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Influence of duration mechanics measured of occlusion time on respiratory with the single‐breath technique in infants
Author(s) -
Mallol Javier,
Willet Karen,
Burton Paul,
Sly Peter D.
Publication year - 1994
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950170409
Subject(s) - medicine , occlusion , cystic fibrosis , respiratory physiology , respiratory system , airway resistance , airway , anesthesia , lung function , pulmonary compliance , lung , surgery
To determine the effect of the length of end‐inspiratory occlusion on the values of respiratory system compliance (C rs and resistance (R rs ) calculated from the single‐breath technique, 6 infants with cystic fibrosis were studied. End‐inspiratory occlusions lasted between 0.3 and 1.2 seconds, and between 8 and 32 separate occlusions were made in each infant. Examination of the individual data showed a systematic tendency for C, to decrease as the length of the airway occlusion increased, with statistical significance reached in two subjects. Using a random effects model, it was demonstrated that there was a decrease of 0.1 5 Ml/cmH 2 O in C rs for each 0.1 s increase in occlusion time. The influence of length of plateau time for C, was similar to that of total occlusion time. No such tendency was seen for R rs . These data reinforce the current emphasis on greater standardization in the methodologies used for infant lung function testing and for more fully reporting methodological details. Pediatr Pulmonol. 1994; 17:250–257. © 1994 Wiley‐Liss, Inc.