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Disseminated aspergillosis in a patient with cystic fibrosis and allergic bronchopulmonary aspergillosis
Author(s) -
Chung Youngran,
Kraut Jerome R.,
Stone Arvey M.,
Valaitis Jonas
Publication year - 1994
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950170210
Subject(s) - allergic bronchopulmonary aspergillosis , medicine , aspergillosis , cystic fibrosis , aspergillus fumigatus , complication , allergy , incidence (geometry) , immunology , immunoglobulin e , antibody , physics , optics
Allergic bronchopulmonary aspergillosis (ABPA) is a, well‐known complication of cysticfibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have other clinical and laboratory features of ABPA (Laufer et al., J Allergy Clin Immunol. 1984; 73:44–48). Once ABPA is identified in a patient, institution of corticosteroids is standard therapy. Invasive aspergillosis is a rare occurrence in patients with CF with or without ABPA, and has been reported in only one young adult who did not have ABPA (Giudotti et al., Am J Med Sci. 1982; 283:157–160). We present a case of a 15‐year‐old male with CF and ABPA who developed disseminated aspergillosis. Pediatr Pulmonol. 1994; 17:131–134 . © 1994 Wiley‐Liss, Inc.