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Nedocromil sodium vs. Sodium cromoglycate pressurized aerosol in the prevention of bronchoconstriction induced by ultrasonic nebulized distilled water in asthmatic children
Author(s) -
Spezia E.,
Del Col G.,
Richelli C.,
Sette L.,
Boner A. L.
Publication year - 1993
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950160406
Subject(s) - nedocromil sodium , bronchoconstriction , medicine , placebo , nedocromil , inhalation , anesthesia , metered dose inhaler , asthma , cromolyn sodium , inhaler , distilled water , chemistry , alternative medicine , pathology , chromatography
To compare the effectiveness of nedocromil sodium (NS) and sodium cromoglycate (SCG), administered by metered dose inhaler (MDI) with a 700 mL holding chamber (Fisonair Fisons UK) in preventing bronchoconstriction induced by inhalation of ultrasonically nebulized distilled water (UNDW), 12 asthmatic children were studied in a randomized, double‐blind, placebo‐controlled, intrapatient study. Following a baseline challenge with UNDW, the protective effect of NS, SCG, or placebo was evaluated in each subject. Cumulative doses of delivered nebulized water producing a 20% fall in forced expiratory volume in 1 sec (PD 20 UNDW) was measured. Mean (± SD) PD 20 , UNDW was 4.83 (± 4.84), 10.16 (± 7.05), 15.8 (± 0.5), and 15.93 (± 0.23) respectively, for baseline, and placebo, SCG, and NS‐treated groups. A significant ( P < 0.05) protection from UNDW induced bronchoconstriction by NS was observed in comparison with placebo, while no such effect was evident when the children were treated with SCG. Pediatr Pulmonol. 1993; 16:243–247. © 1993 Wiley‐Liss, Inc.