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Atrial natriuretic factor and pulmonary status in premature infants with respiratory distress syndrome: Preliminary investigation
Author(s) -
Pesonen Erkki,
Heldt Gregory P.,
Allen Merritt T.,
Sahn David J.,
Elias William,
Tikkanen Ilkka,
Fyhrquist Frej,
Andersson Sture
Publication year - 1993
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950150609
Subject(s) - medicine , respiratory distress , respiratory system , lung , pulmonary compliance , respiratory disease , cardiology , anesthesia , endocrinology
We studied the correlation of atrial natriuretic factor (ANF) with lung compliance in a series of 16 premature infants with respiratory distress syndrome (RDS). The infants were followed during the first week of life by sequential Doppler echocardiography, lung compliance, and ANF measurements. Plasma ANF concentration varied between 38 and 2220 pg/mL; mean concentrations of 393 and 123 pg/mL with the ductus open and with it closed, respectively ( P < 0.01). The arteriolar/alveolar oxygen‐tension ratio showed an inverse correlation with the logarithm (In) of the ANF concentration ( r = −0.55, P = 0.0002). Both mean airway pressure and In ANF showed an inverse correlation with the arteriolar/alveolar oxygen tension ratio (R = −0.77, F = 20.5 and 13.8, respectively). Plasma ANF was inversely correlated to lung compliance ( r = −0.64, P < 0.0001). In infants with RDS, plasma ANF concentrations increase with the severity of respiratory distress. Because ANF increases endothelial permeability, in this preliminary investigation lead to the hypothesis that it may contribute to respiratory distress by causing extravasation of fluid from the pulmonary circulation in these patients. © 1993 Wiley‐Liss, Inc.