Research Library

Premium Cytokines in sputum and serum from patients with cystic fibrosis and chronic pseudomonas aeruginosa infection as markers of destructive inflammation in the lungs.
Author(s)
Kronborg Gitte,
Hansen Morten B.,
Svenson Morten,
Fomsgaard Anders,
Hsiby Niels,
Bendtzen Klaus
Publication year1993
Publication title
pediatric pulmonology
Resource typeJournals
PublisherWiley Subscription Services
Abstract The presence of interleukin (IL)–1 receptor antagonist (IRAP) in plasma and sputum from patients with cystic fibrosis (CF) and chronic Pseudomonas aeruginosa lung infection was investigated together with IL‐lα, IL‐1β, IL‐6, and tumor necrosis factor‐α (TNF) in a cross‐sectional study. All cytokines were assayed by ELISAs. High concentrations of IRAP, IL‐lα, IL‐1β, IL‐6, and TNF in sputum samples and low or nondetectable levels of circulating cytokines were frequently found. Increased concentrations of plasma RAP are positively correlated with decreasing pulmonary function. In a longitudinal study of serum IRAP, a higher level of RAP was detected in a group of patients with poor pulmonary function compared to a group with good pulmonary function. © 1993 Wiley‐Liss, Inc.
Subject(s)antagonist , bacteria , biology , cystic fibrosis , cytokine , fibrosis , gastroenterology , genetics , immunology , inflammation , interleukin , interleukin 1 receptor antagonist , lung , medicine , pathology , pseudomonas aeruginosa , pulmonary function testing , receptor , receptor antagonist , respiratory disease , sputum , tuberculosis , tumor necrosis factor alpha
Language(s)English
SCImago Journal Rank0.866
H-Index106
eISSN1099-0496
pISSN8755-6863
DOI10.1002/ppul.1950150506

Seeing content that should not be on Zendy? Contact us.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here