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Assessment of forced expiratory volume — time parameters in detecting histamine‐induced bronchoconstriction in wheezy infants
Author(s) -
Turner Debra J.,
Sly Peter D.,
Lesouëf Peter N.
Publication year - 1993
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950150407
Subject(s) - bronchoconstriction , medicine , anesthesia , asthma , histamine , volume (thermodynamics) , airway , physics , quantum mechanics
A new technique recently introduced allows the measurement of infant lung function from lung volumes raised by a pump prior to generation of forced expiratory flow‐volume (FEFV) curves. Forced expiratory volume‐time (FEV 1 ) parameters rather than traditional flow parameters are used. The aim of this study was to assess the usefulness of FEV, parameters in detecting airway responsiveness to histamine in recurrently wheezy infants. Ten infants (age 7–18 months) sedated with 80 mg/kg chloral hydrate underwent a histamine inhalation challenge. Throughout the challenge FEFV curves were generated from end‐tidal inspiration. Raised FEFV curves, from a lung volume preset by 15 cmH 2 O inflation pressure, were gathered at baseline and after the final concentration of histamine. The mean fall from baseline was 47% in maximal flow at functional residual capacity (VmaxFRC) (P < 0.0005), 15.5% in FEV 0.5 (P < 0.000l), 13.5% in FEV 0.75 (P < 0.005), and 11.0% in FEV 1.0 (P = 0.057), after the final concentration of histamine delivered. Tidal volume and inspiratory volume reached above FRC between pre‐ and posthista‐mine did not change. Mean oxygen saturation fell significantly from 97 to 93%. We conclude that FEV 1 parameters adequately detect reduced lung function during histamine‐induced bronchoconstriction and appear suitable for histamine challenge testing in infants. © 1993 Wiley‐Liss, Inc.