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Reproducibility of late phase pulmonary response to exercise and its relationship to bronchial hyperreactivity in children with chronic asthma
Author(s) -
Boner A. L.,
Vallone G.,
Chiesa Mo M.,
Spezia E.,
Fambri Mid L.,
Sette Yd L.
Publication year - 1992
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950140304
Subject(s) - medicine , asthma , bronchial hyperreactivity , reproducibility , respiratory disease , physical therapy , lung , statistics , mathematics
To determine the reproducibility of the delayed response to exercise and its effect on bronchial hyperreactivity, we had 26 asthmatic children perform treadmill exercise challenge on two occasions 1 week apart. Both challenges were preceded by 2 control days and 1 histamine challenge day, and were followed by another histamine challenge day. Peak expiratory flow rate (PEFR) was measured hourly for 12 hours on each control day and for 12 hours after each exercise or histamine challenge. During the first week, five patients showed a late reaction (PEFR change > 15%) after exercise, which was present in only two of them the following week. These two patients, however, also showed a spontaneous fall > 15% of PEFR from baseline during the other control study days. A similar pattern was seen in two other patients who had a late response during the second exercise challenge but not during the first. No significant change occurred in histamine PC‐20 FEV 1 between before and after the exercise challenges. An apparent late asthmatic response after exercise challenge may represent a within‐day fluctuation in pulmonary mechanics that develops spontaneously in children with asthma. © 1992 Wiley‐Liss, Inc.