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Noninvasive breathing analysis: Repetitive chloral hydrate in neonatal guinea pigs
Author(s) -
Olsen George D.,
Weil Jeffrey A.
Publication year - 1992
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950130410
Subject(s) - chloral hydrate , respiratory rate , medicine , tidal volume , anesthesia , placebo , breathing , heart rate , respiratory system , alternative medicine , pathology , blood pressure
A noninvasive method was used to record neonatal breathing, heart rate (HR), and the electroencephalogram (EEG) in guinea pig pups. Neonates were randomly assigned at birth to chloral hydrate (CH) or placebo (PLA) treatment. Treatments were administered 30 min before each study on days 1, 3, 5, 7, 14, and 21 after birth. Animals were studied while they breathed room air followed by air with 5% CO 2 and 30% O 2 . CH decreased breathing frequency (f) and inspiratory minute volume ( \documentclass{article}\pagestyle{empty}\begin{document}$ \mathop {\rm V}\limits^. $\end{document} I ), but not tidal volume (V T ) during the first week ( P < 0.05), and reduced the rate of growth throughout the study ( P < 0.01), whereas breathing of CO 2 increased f, V T , \documentclass{article}\pagestyle{empty}\begin{document}$ \mathop {\rm V}\limits^. $ \end{document} I , HR, and the relative power in the delta frequency band of the EEG. The percent change in V I induced by CO 2 , however, was not affected by drug treatment. There was a significant day of life effect on all breathing parameters and HR. CH has cumulative effects on breathing and growth that should be considered when it is used as a sedative for repeated neonatal studies in guinea pigs. © 1992 Wiley‐Liss, Inc.