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Cardiorespiratory effects of changing inspiratory to expiratory ratio during high‐frequency oscillation in an animal model of respiratory failure
Author(s) -
Courtney Sherry E.,
Weber Kaye R.,
Spohn William A.,
Bender Charles V.,
Malin Seth W.,
Gotshall Robert W.
Publication year - 1992
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950130210
Subject(s) - medicine , cardiorespiratory fitness , mean airway pressure , cardiology , ventilation (architecture) , respiratory system , blood pressure , anesthesia , oxygenation , high frequency ventilation , peak inspiratory pressure , cardiac output , mechanical ventilation , tidal volume , physics , thermodynamics
To examine the effects of varying inspiratory/expiratory ratio (I/E) on cardiorespiratory function during high‐frequency oscillation (HFO), 11 saline‐lavaged rabbits were ventilated at I/E = 1:2, 1:1.5, 1.5:1, and 2:1 in a paired comparison to a baseline of I/E = 1:1. HFO was delivered by a SensorMedics model 3100 oscillator at a frequency of 10 Hz. Pressure amplitude and proximal mean airway pressure (P P aw) were held constant as I/E was varied from baseline to the experimental I/E. During each paired observation, Pa O 2, Pa CO 2, cardiac output, blood pressure, and distal mean airway pressure (D P aw) were measured. © 1992 Wiley‐Liss, Inc. We found that as I/E was increased or decreased from 1:1, no significant changes in Pa O 2, Pa CO 2, blood pressure, or cardiac output occurred. We conclude that in this model, varying I/E has no significant effect on oxygenation, ventilation, or cardiovascular function.