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Fat‐soluble vitamins in infants identified by cystic fibrosis newborn screening
Author(s) -
Sokol Ronald J.,
Reardon Mary C.,
Accurso Frank J.,
Stall Charlotte,
Narkewicz Michael R.,
Abman Steven H.,
Hammond Keith B.
Publication year - 1991
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950110711
Subject(s) - cystic fibrosis , medicine , fat soluble vitamin , vitamin , vitamin d deficiency , vitamin a deficiency , retinol , vitamin d and neurology , newborn screening , vitamin k deficiency , pancreatic enzymes , pancreatic disease , endocrinology , gastroenterology , physiology , pediatrics , pancreas
Fat‐soluble vitamin status was assessed in 36 infants diagnosed with cystic fibrosis by newborn screening in the Colorado Program. At the time of diagnosis of cystic fibrosis, 36% of infants were hypoalbuminemic, 21% had vitamin A deficiency, 35% had vitamin D deficiency, and 38% had vitamin E deficiency. None had vitamin K deficiency. Supplementation with pancreatic enzymes, a multiple vitamin preparation, and additional vitamin E was associated with normalization of serum albumin, retinol, and 25‐hydroxyvitamin D and negative PIVKA testing at age 6 and 12 months. Several patients remained vitamin E deficient, but this was felt to be due to poor compliance. Biochemical evidence of fat‐soluble vitamin deficiency is common before age 3 months in infants with CF and responds to supplementation in the first year of life. Pediatr Pulmonol. 1991; Supp 7: 52–55.