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Comparison of FEV 1 and transcutaneous oxygen tension in the measurement of airway responsiveness to methacholine
Author(s) -
van Broekhoven P.,
Hop W. C. J.,
Rasser E.,
de Jongste J. C.,
Kerrebijn K. F.
Publication year - 1991
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950110312
Subject(s) - medicine , methacholine , anesthesia , airway , physical therapy , respiratory disease , lung
The measurement of airway responsiveness in preschool children is hampered by the fact that most tests of airway caliber are difficult to carry out at a young age. Patient cooperation is only needed to a limited extent when transcutaneous oxygen tension (Ptc O 2) is used as an indicator of airway obstruction following bronchial provocation. In 51 children, aged 6–14 years with asthma we have measured Ptc O 2and forced expiratory volume in 1 second (FEV 1 ) concurrently after bronchial provocation, using increasing doses of methacholine administered with a De Villbiss 646 nebulizer and a French‐Rosenthal dosimeter. The shapes of the dose‐response curves to Ptc O 2and FEV 1 show a close similarity. After methacholine challenge, the decrease in Ptc O 2correlates highly with the decrease in FEV 1 . We conclude that in children a 20% decrease in Ptc O 2can be used as a sensitive indicator of airway narrowing after methacholine challenge.