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Clinical observations on lower respiratory tract infections with special reference to serum IgE levels
Author(s) -
Nagayama Yoko,
Sakurai Nobukiyo
Publication year - 1991
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950110108
Subject(s) - medicine , mycoplasma pneumoniae , immunoglobulin e , respiratory tract , respiratory tract infections , incidence (geometry) , immunology , asthma , lower respiratory tract infection , respiratory system , respiratory disease , mycoplasma , pneumovirinae , pneumovirus , paramyxoviridae , virus , pneumonia , viral disease , lung , antibody , microbiology and biotechnology , biology , physics , optics
To examine if the occurrence of wheezing among children with lower respiratory tract infections is associated with atopic predisposition, serum levels of IgE were determined for groups of children with or without wheezing, during infection with Mycoplasma pneumoniae or respiratory syncytial virus (RSV). In M. pneumoniae infection, more than 60% of wheezy children over 2 years of age showed a high IgE level (200 IU/mL or more), while IgE levels were less than 200 IU/mL in 73% of non‐wheezy children. In RSV infection, the incidence of high IgE levels among wheezy children was nearly double that of non‐wheezy children, although the difference was not significant. These results suggest that in children an allergic disposition is involved in the occurrence of wheezing during the course of lower respiratory tract infections.Pediatr Pulmonol. 1991; 11:44‐48