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Repeated provocation tests in asthmatic children for testing tachyphylaxis to histamine
Author(s) -
Roorda Ruurd Jan,
Gerritsen Jorrit,
van Aalderen Wim M. C.,
Schouten Jan P.,
Knol Klaas
Publication year - 1991
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950100212
Subject(s) - tachyphylaxis , histamine , medicine , asthma , provocation test , confidence interval , anesthesia , pathology , alternative medicine
Tachyphylaxis to histamine was investigated in 16 children, aged 7–15 years, with mild asthma. Three consecutive histamine challenges were performed at intervals of 24 hours and 1 hour, respectively. No significant differences in IVC, FEV 1 , and PC 20 ‐histamine values between the three measurements were observed. After a 24 hour interval there was no difference in percentage fall of FEV 1 , but there was a slight (not significant) decrease in fall of FEV 1 after a 1 hour interval. The PC 20 ‐histamine values showed good reproducibility with a 24 hour as well as with a 1‐hour period between the tests (geometric mean PC 20 , 2.04 mg/mL ± 3.50 %SD, 1.96 mg/mL ± 4.37 %SD, 2.17 mg/mL ± 4.12 %SD; correlation coefficients for a 24 hour interval, r = 0.87 and for a one‐hour interval, r = 0.94 ( P < 0.01)). We conclude that in children there is no strong evidence for tachyphylaxis to histamine. Our results differ from studies on tachyphylaxis in adult asthmatics. Possibly different mechanisms exist in children and in adults. Pediatr Pulmonol 1991; 10:106–111.