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Surfactant protein‐A in bronchoalveolar lavage fluid from neonates with RDS on conventional and high‐frequency oscillatory ventilation
Author(s) -
Gerdes Jeffrey S.,
Abbasi Soraya,
Karp Karen,
Hull William,
Whitsett Jeffrey A.
Publication year - 1990
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950090308
Subject(s) - bronchoalveolar lavage , pulmonary surfactant , medicine , high frequency ventilation , respiratory distress , ventilation (architecture) , mechanical ventilation , respiratory disease , surfactant protein d , lung , anesthesia , biology , biochemistry , receptor , engineering , innate immune system , mechanical engineering
Surfactant protein‐A (SP‐A) was measured in bronchoalveolar lavage (BAL) samples from ventilated neonates in order to study the concentration of SP‐A with regard to: 1) high‐frequency oscillatory ventilation (HFOV) vs. conventional mechanical ventilation (CMV); 2) the postnatal course and ontogeny of SP‐A; and 3) the correlation with measurements of pulmonary function. Patients on HFOV had markedly lower BAL SP‐A concentrations on days 1 and 2 compared to those on CMV, which may indicate influence of mode of ventilation on surfactant metabolism. The SP‐A concentrations increased postnatally concurrent with resolution of acute respiratory distress syndrome. Finally, there were only weak correlations between BAL SP‐A concentration and dynamic lung compliance and oxygen requirement. Pediatr Pulmonal 1990; 9:166–169 .