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Pulmonary function in infancy and in childhood following mechanical ventilation in the neonatal period
Author(s) -
Lebourges F.,
Moriette G.,
Boulé M.,
Delaperche M. F.,
Relier J. P.,
Gaultier C.
Publication year - 1990
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950090108
Subject(s) - medicine , functional residual capacity , ventilation (architecture) , respiratory distress , pulmonary function testing , mechanical ventilation , respiratory system , pulmonary compliance , anesthesia , lung function , respiratory disease , lung volumes , lung , pediatrics , mechanical engineering , engineering
Pulmonary function was evaluated in both infancy and childhood in the same 19 prematurely born infants, who required mechanical ventilation (MV) during the neonatal period. Results of our patients were compared with those of control subjects. Upon first evaluation, we found that lung resistance (R L ) was significantly elevated (24.85 ± 6.06 vs. 17.77 ± 2.39 cmH 2 O/L/s; P < 0.01). The mean value of dynamic lung compliance (C Ldyn ) was low, but the difference compared to controls did not reach significance. From infancy to childhood, elevated R L persisted (9.33 ± 2.51 vs. 6.52 ± 1.52 cm H 2 O/L/s; P < 0.01), and the decrease of C Ldyn became significant (46.86 ± 12.84 vs. 59.34 ± 15.68 mL/cmH 2 O; P < 0.05). In addition, maximum flow at functional residual capacity was significantly decreased (0.824 ± 0.284 vs. 1.215 ± 0.358 L/s; P < 0.01); whereas pulmonary diffusing capacity for carbon monoxide was similar in the patients (7.62 ± 2.16 mL/min/mm Hg) and in the controls (8.38 ± 1.6). Pulmonary dysfunction following premature birth, respiratory distress, and prolonged MV may not resolve from infancy to childhood. Pediatr Pulmonol 1990; 9:34–40 .