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Compliance, alveolar–arterial oxygen difference, and oxygenation index changes in patients managed with extracorporeal membrane oxygenation
Author(s) -
Brudno D. Spencer,
Boedy R. Frederick,
Kanto William P.
Publication year - 1990
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950090105
Subject(s) - medicine , extracorporeal membrane oxygenation , oxygenation index , oxygenation , meconium aspiration syndrome , pulmonary compliance , anesthesia , membrane oxygenator , lung , respiratory failure , compliance (psychology) , meconium , cardiology , fetus , pregnancy , social psychology , psychology , biology , genetics
Eighteen patients with meconium aspiration syndrome who failed conventional management were treated with extracorporeal membrane oxygenation (ECMO) for reversible respiratory failure. Dynamic lung compliance measurements were made prior to, during, and after ECMO support. P(A‐a) O 2 and oxygenation index (Ol) measurements were calculated prior to and after ECMO support. Lung compliance decreased significantly comparing before‐ECMO to during‐ECMO, and increased significantly comparing during‐ to after‐ECMO, but not comparing before‐ to after‐ECMO measurements. P(A‐a) O 2 and Ol decreased significantly from before to after ECMO. The improvement in oxygenation allowing removal from ECMO does not appear to be related to improved pulmonary mechanics, but may rather be secondary to increased effective pulmonary capillary blood flow. Pediatr Pulmonol 1990; 9:19–23 .