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Transcutaneous blood gas analysis during sleep and exercise in cystic fibrosis
Author(s) -
Pradal U.,
Braggion C.,
Mastella G.
Publication year - 1990
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950080306
Subject(s) - medicine , cystic fibrosis , hypercapnia , arterial blood , anesthesia , cardiology , respiratory system , surgery
Forty patients with cystic fibrosis (CF) (mean age, 13 ± 2.5 years) were studied with transcutaneous (tc) blood gas monitoring (TCM) during sleep and exercise. By comparing arterial blood samples and TCM in 24 of them (27 samples), a mean bias of tc O 2–15.91 mmHg with a precision of 8.4 mmHg was found. The mean bias of tc CO 2was 7.21 mmHg with a precision of 3.9 mmHg. A standardized submaximal exercise test (1.7 W/kg) was performed in all 40 CF patients and in 14 healthy control subjects (mean age, 13 ± 0.5 years). The typical tc trend during exercise for CF and healthy subjects was a slight increase of tc O 2levels and tc CO 2stability. A minor decrease of tc CO 2values occurred in four CF patients (no greater than 7 mmHg). In 28 patients (mean age, 13 ± 3 years), tc O 2and tc CO 2were recorded during sleep. In 13 of them, apparent hypoxemic episodes were noted, without relation to the degree of airway obstruction. There were simultaneous episodes of hypercapnia in ten patients. Some difficulties were encountered in analyzing long‐term recordings. Tc O 2drifts upward and tc CO 2decreases during the recordings over several hours. The change in electrode position after 4 h of sleep modified tc O 2and tc CO 2values. Such difficulties limit the usefulness of long‐term but not short‐term recordings. Pediatr Pulmonol 1990; 8:162‐167.