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Differential rates of lung growth as measured longitudinally by pulmonary function in children and adolescents
Author(s) -
Sherrill Duane,
Holberg C. J.,
Lebowitz M. D.
Publication year - 1990
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950080304
Subject(s) - medicine , pulmonary function testing , vital capacity , anthropometry , population , lung volumes , spirometry , pediatrics , lung function , demography , cardiology , asthma , lung , diffusing capacity , environmental health , sociology
A sample population of 67 males and 71 females with longitudinal lung function and other anthropometric measurements from all non‐Hispanic white children in the Tucson Epidemiological Study of Airway Obstructive Diseases (AOD) was studied to evaluate biological determinants of the rate of lung growth. Groups within gender were defined by the following factors: 1) maximum height, 2) age at maximum forced expiratory volume at 1 second (FEV 1 ), 3) % predicted initial FEV 1 or FEV 1 /FVC ratio. Only groups defined by low initial function (FEV 1 or FEV 1 /FVC ≤ 85% predicted versus >85% predicted) showed statistically significant differences from those with more “normal” function by comparing their maximum % of predicted FEV 1 s and FEV 1 /FVC ratios. The longitudinal FEV 1 data by age for the latter groups were characterized by a mathematical model (polynomial smoothing spline) yielding optimal fitted curves and an estimate of each group's growth velocity curve. The statistical comparisons between these fitted curves indicate that subjects with low initial pulmonary function continued to have significantly lower FEV 1 values for males older than 13.12 years and for females between 8.23 and 15.3 years. At post‐hoc analysis persistent wheezing was more likely in the initially more impaired group. Disease at the end of follow‐up was not related to initial functional status. Pediatr Pulmonol 1990; 8:145‐154.