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Hypercapnia in relation to pulmonary function in duchenne muscular dystrophy
Author(s) -
Canny Gerard J.,
Szeinberg Amir,
Levison Henry,
Koreska Jan
Publication year - 1989
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950060308
Subject(s) - medicine , duchenne muscular dystrophy , hypercapnia , pulmonary function testing , muscular dystrophy , cardiology , physical medicine and rehabilitation , respiratory system
Arterialized blood gases were analyzed in 143 patients with Duchenne muscular dystrophy (DMD) to assess the relationship between forced vital capacity (FVC) and hypercapnia. The majority of patients studied had Pa co2 values in the low or normal range. Only six older patients had hypercapnia (Pa co2 ≥ 45 mm Hg), and all these patients had FVC values ⩽ 40% predicted. We conclude that hypercapnic respiratory failure occurs as a late preterminal event in DMD.