Premium
Changes in pulmonary mechanics following caffeine administration in infants with bronchopulmonary dysplasia
Author(s) -
Davis Jonathan M.,
Bhutani Vinod K.,
Stefano John L.,
Fox William W.,
Spitzer Alan R.
Publication year - 1989
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950060112
Subject(s) - bronchopulmonary dysplasia , medicine , caffeine , placebo , pulmonary function testing , anesthesia , pulmonary compliance , respiratory physiology , ventilation (architecture) , tidal volume , lung , respiratory system , gestational age , pregnancy , mechanical engineering , genetics , alternative medicine , pathology , engineering , biology
The effects of caffeine upon pulmonary mechanics were measured in 16 infants with bronchopulmonary dysplasia (BPD). Pulmonary function tests were performed immediately prior to and 1 hour following a dose of 10 mg/kg of caffeine. A 37% increase in minute ventilation (mean ± SEM; 436.6 ± 26.3 to 580.8 ± 30.7 ml/min/kg) was seen with caffeine administration (P < 0.001), primarily from a 42% increase in tidal volume (6.2 ± 0.4 to 8.5 ± 0.4 ml/kg) ( P < 0.001). Total lung resistance decreased by 20% (134.6 + 24.2 to 105.3 ± 20.1 cmH 2 O/L/sec) ( P = 0.01), and total pulmonary compliance improved by 47% (0.642 ± 0.104 to 0.908 ± 0.190 ml/cmH 2 O/kg) ( P < 0.01). In five matched control infants with BPD, no effects of placebo upon pulmonary mechanics were detected. Since caffeine has a wide therapeutic index with few side effects, it may be an effective adjunct in the treatment of infants with BPD.