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A trial of metaproterenol by metered‐dose inhaler and two spacers in preschool asthmatics
Author(s) -
König Peter,
Gayer Debra,
Kantak Anand,
Kreutz Cynthia,
Douglass Barbara,
Hordvik Nancy Louise
Publication year - 1988
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950050412
Subject(s) - medicine , bronchodilation , crossover study , anesthesia , inhaler , metered dose inhaler , placebo , asthma , bronchodilator , alternative medicine , pathology
Because most young children have difficulty in coordination for correct use of metered‐dose inhalers (MDI), a trial of two spacer devices attached to MDls was performed. In 13 children with asthma, aged 2–5 years old, a collapsible bag (Inspir‐Ease) and a tube spacer (Aerochamber) were tested in a double‐blind crossover trial with metaproterenol (1,300 μg). Respiratory resistance was measured by the forced oscillation method. Thirty minutes after metaproterenol administration there was a significant decrease in resistance with both spacers, while no significant change occurred after placebo administration. There was no difference in degree of bronchodilation between the two spacers. It is concluded that metaproterenol can be safely and effectively administered to preschool asthmatics by an MDI with spacer devices.