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Histamine‐induced airway obstruction in infancy: Changes in oxygenation
Author(s) -
Prendiville Anne,
Maxwell David L.,
Rose Alison,
Silverman Michael
Publication year - 1988
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950040308
Subject(s) - medicine , anesthesia , oxygenation , histamine , airway obstruction , oxygen saturation , hyperventilation , airway , oxygen , chemistry , organic chemistry
In seven recurrently wheezy infants who were found to be histamine‐responsive during bronchial challenge, changes in oxygenation (by oximeter and transcutaneous P o 2 electrode) and carbon dioxide tension (by transcutaneous P co 2 electrode) were concurrently measured. The histamine challenge consisted of doubling concentrations administered by nebulizer for 1 min at 5‐min intervals, up to a maximum concentration of 8 g/L. The response was determined from maximum expiratory flow using a squeeze technique. Significant mean reductions in transcutaneous oxygen tension of 0.9 ± 0.7 kPa and 1.5 ± 0.9 kPa were seen respectively at half the provoking concentration and at the provoking concentration of histamine that caused a significant reduction in maximum expiratory flow rates. The reduction in oxygen saturation of 4.8 ± 3% was also significant at the provoking concentration. No significant change in transcutaneous carbon dioxide tension was seen. These results suggest that acute histamine‐induced airway obstruction causes significant ventilation/perfusion disturbance in wheezy infants. Oxygen monitoring should be performed during bronchial challenge tests in infancy.