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Effect of pulmonary hypertension on lung compliance in newborn lambs
Author(s) -
Caeton A. John,
Goetzman Boyd W.,
Bennett Stephen H.,
Milstein Jay M.
Publication year - 1987
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950030508
Subject(s) - medicine , vascular resistance , pulmonary hypertension , pulmonary artery , lung , pulmonary compliance , compliance (psychology) , cardiology , hypoxia (environmental) , anesthesia , acidosis , pulmonary gas pressures , blood pressure , psychology , social psychology , chemistry , organic chemistry , oxygen
We studied the effects of increased pulmonary arterial pressure and vascular resistance on lung compliance in 12 anesthetized newborn lambs. Lung compliance was unaffected by large changes in pulmonary artery pressure and pulmonary vascular resistance (80% increase) that were induced by either hypoxia or acidosis. We conclude that contraction of the pulmonary vascular smooth muscle in normal newborn lambs does not affect the stiffness of the lung in the parenchymal regions undergoing volume change during ventilation. Pediatr Pulmonol 1987; 3:324–327 .