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Pulmonary function at 1 year of age in survivors of neonatal respiratory distress: A multivariate analysis of factors associated with sequelae
Author(s) -
Moriette G.,
Gaudebout C.,
Clement A.,
Boule M.,
Bion B.,
Relier J. P.,
Gaultier C.
Publication year - 1987
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950030409
Subject(s) - medicine , multivariate analysis , respiratory distress , multivariate statistics , pediatrics , respiratory system , pulmonary function testing , distress , lung function , respiratory disease , intensive care medicine , lung , surgery , clinical psychology , statistics , mathematics
Abstract We studied pulmonary function 1 year after neonatal respiratory distress (RD) in 54 infants who had been treated at birth in the same neonatal intensive care unit. RD was related to hyaline membrane disease in 36 cases (group 1) and to other causes in 18 cases (group II). Compared with predicted values, dynamic lung compliance (C L ) was lower (< −2 SD) and total pulmonary resistance (RL) was higher (+ 2 SD) in 18 (33%) and 12 (22%) infants, respectively. The relationships between these functional abnormalities at 1 year of age and the characteristics of the neonatal respiratory disease were assessed using a multifactorial analysis (multiple correspondences analysis). We found that elevated R L (> +2 SD) at 1 year of age was very significantly related with hyaline membrane disease, involving both high rate of positive pressure ventilation and prolonged intubation, and with the presence of both tachypnea and abnormal chest X rays at the time of discharge. Compared with elevated R L , the relationships between low C L (< −2 SD) and the same neonatal characteristics were less significant; in particular, there was no strong link between low C L and hyaline membrane disease. Finally, birth before 30 weeks gestation was an index of severity.