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Changes in cerebrospinal fluid homovanillic acid in children with Ondine's curse
Author(s) -
Hedner J.,
Hedner T.,
Breese G. R.,
Lundell K. H.,
Lundberg D.,
Lundström N. R.,
Østergaard E.,
McCown T. J.,
Mueller R. A.
Publication year - 1987
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950030216
Subject(s) - homovanillic acid , dopamine , cerebrospinal fluid , medicine , metabolite , endocrinology , monoamine neurotransmitter , anesthesia , serotonin , receptor
The cerebrospinal fluid (CSF) concentrations of three acid monoamine metabolites, two purines, and a group of amino acids were determined in two children with chroniccentral alveolar hypoventilation (Ondine's curse). The levels of all assayed neuroactive substances, metabolites, and amino acids, with one exception, were normal compared to an age‐matched group of neurologically healthy children. The levels of the dopamine metabolite homovanillic acid in the children with Ondine's curse were approximately 2.4 times higher than expected for age range. The present findings may indicate a link between central nervous system dopamine activity and chronic central alveolar hypoventilation. Among other possible explanations, the changes seen might represent a primary alteration in dopamine activity or may reflect a change in dopamine turnover resulting from the chronic hypoventilation. Pediatr Pulmonol 1987; 3:131–135 .