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Therapeutic evaluation of piperacillin for acute pulmonary exacerbations in cystic fibrosis
Author(s) -
Reed Michael D.,
Stern Robert C.,
Myers Carolyn M.,
Klinger Jeffrey D.,
Yamashita Toyoko S.,
Blumer Jeffrey L.
Publication year - 1987
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950030212
Subject(s) - piperacillin , medicine , sputum , cystic fibrosis , regimen , adverse effect , pharmacokinetics , vomiting , gastroenterology , anesthesia , pseudomonas aeruginosa , pathology , tuberculosis , genetics , bacteria , biology
The efficacy and pharmacokinetics of piperacillin monotherapy were studied in 46 patients with cystic fibrosis. Two patients were dropped from the study within 24 hr of enrollment because of drug‐associated nausea and vomiting. Initially fourteen older patients (> 12 years) receiving piperacillin 450 mg/kg/day underwent a preliminary evaluation. Based on the results, 30 younger patients (⩽ 12 years) randomized in a double‐blind fashion received either 600 or 900 mg/kg/day of piperacillin in six divided doses. Pharmacokinetic parameter estimates for t 1/2 , Vdss, and Cl were similar for first dose and steady‐state evaluations. In 27 patients, approximately 43% of the administered dose was recovered in the urine after 4 hr. Piperacillin Ci R averaged 49% of the total Cl. No difference in overall clinical efficacy could be identified between 600 and 900 mg/kg/day of piperacillin using two different objective scoring systems. Although a reduction in sputum Pseudomonas colony counts was greater following the 900 mg/kg/day regimen, this appeared to be independent of clinical effect. In 14 patients (32%), a distinct adverse serum‐sicknesslike reaction was observed. The incidence of this reaction appeared to increase as the dose of piperacillin increased. All signs and symptoms of this reaction resolved within 36 hr of discontinuing piperacillin administration but recurred immediately on rechallenge in four patients. All patients with the adverse reaction were subsequently treated with β‐lactam antibodies without ill effect. Overall, clinical improvement appeared to be independent of the piperacillin dose. Our data support the use of total daily piperacillin dosages not exceeding 600 mg/kg. Pediatr Pulmonol 1987; 3:101–109 .