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Decreased phosphatidyl choline content in bronchoalveolar lavage fluids of children with bronchopulmonary dysplasia: A preliminary investigation
Author(s) -
Clement A.,
Masliah J.,
Housset B.,
Just J.,
Garcia J.,
Grimfeld A.,
Tournier G.
Publication year - 1987
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950030205
Subject(s) - bronchopulmonary dysplasia , medicine , bronchoalveolar lavage , gestational age , gastroenterology , respiratory disease , pulmonary surfactant , choline , birth weight , respiratory failure , lung , respiratory system , pregnancy , genetics , physics , biology , thermodynamics
Bronchoalveolar lavage (BAL) was performed on 12 infants who had recovered from neonatal acute respiratory failure and on 12 patients with bronchopulmonary dysplasia (BPD) in order to evaluate the concentration of phosphatidyl choline (PC) in BAL fluid These two groups were similar at birth (mean birth weight: 1,980 and 1,750 g, respectively; mean gestational age: 33.4 and 32.1 weeks respectively). Mechanical ventilation based on oxygen requirement lasted longer in the group with BPD. BAL was performed at the end of the first year of life (at 8.5 and 10.3 months, respectively) and the results were compared to control values (from infants of the same age without neonatal disease). Whereas the protein concentration in BAL fluid was similar in the two groups, a dramatic decrease of the BAL PC was found in BPD: The mean values of BAL‐PC over protein ratio were 0.9 in the group without pulmonary sequelae and 0.3 in the group with BPD These preliminary results suggest an impairment of the pulmonary surfactant metabolism in this chronic lung disease following neonatal acute respiratory failure. Pediatr Pulmonol 1987; 3:67–70 .