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Physiologic effects of terbutaline on pulmonary function of infants with bronchopulmonary dysplasia
Author(s) -
Sosulski Richard,
Abbasi Soraya,
Bhutani Vinod K.,
Fox William W.
Publication year - 1986
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950020504
Subject(s) - medicine , bronchopulmonary dysplasia , terbutaline , anesthesia , pulmonary function testing , pulmonary compliance , lung function , respiratory physiology , lung , cardiology , asthma , gestational age , pregnancy , biology , genetics
This study defines the physiologic changes in pulmonary mechanics induced by subcutaneous terbutaline administration in ventilator‐dependent infants with severe bronchopulmonary dysplasia (BPD). Eight such infants (mean ± SEM weight = 2.56 ± 0.32kg, postnatal age = 13.0 ± 3.2 weeks) were chosen for the study. Pulmonary mechanics and arterial blood gases were measured in the control state and at 30 and 60 minutes following the subcutaneous injection of 5 μg/kg terbutaline. There was a significant (p < 0.001) improvement in lung compliance from baseline values at 30 minutes and at 60 minutes (38%). A significant (p < 0.05) decrease of 23% in the average pulmonary resistance at 30 minutes and a 26% decrease at 60 minutes from control values were observed. An increase in the I/E ratio occurred in all patients at 60 minutes (p < 0.01). In addition, clinical improvement was noted in six of eight infants. Administration of terbutaline demonstrated a significant improvement in the pulmonary mechanics of infants with severe BPD.