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Liposyn infusion increases plasma prostaglandin concentrations
Author(s) -
Hunt Carl E.,
Pachman Lauren M.,
Hageman Joseph R.,
Cobb Michael A.,
Klemka Linda
Publication year - 1986
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950020307
Subject(s) - radioimmunoassay , thromboxane , medicine , metabolite , endocrinology , prostaglandin , thromboxane b2 , plasma concentration , prostaglandin e , vasodilation , prostacyclin , platelet
To determine whether Liposyn infusion results in increased plasma prosta‐glandin (PG) concentrations, the following study was performed in 33 adult rabbits with chronically implanted arterial and venous catheters. Plasma PG concentrations were determined by radioimmunoassay for two vasodilators, PGE 2 and PGI 2 (as measured by its metabolite 6‐keto‐PGF 1α ), and two vasoconstrictors, thromboxane (TX) A 2 , and PGF 2α , as measured by their metabolites TXB 2 and PGF 2α ‐M, respectively. A 1‐hour infusion of Liposyn at 4 ml per kg resulted in statistically significant increases in arterial and venous concentrations of PGE 2 and 6‐keto‐PGF 1α (p < 0.001) and of TXB, (p < 0.04). There were no significant changes in PGF 2α ‐M plasma concentrations. Liposyn infustion also resulted in a small but statistically significant increase in Pao 2 of 4.7 ± 1.5 torr (p < 0.01). It is concluded that Liposyn infusion results in statistically significant increases in plasma concentrations of PGE 2 , 6‐keto‐PGF 1α , and TXB 2 .