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Cold air provocation of airway hyperreactivity in patients with cystic fibrosis
Author(s) -
Darga Linda L.,
Eason Lawrence A.,
Polgar George,
Zach Dozent Maximilian S.
Publication year - 1986
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950020205
Subject(s) - medicine , cystic fibrosis , airway , provocation test , bronchial hyperreactivity , lung volumes , incidence (geometry) , cardiology , vital capacity , asthma , lung , anesthesia , respiratory disease , gastroenterology , lung function , pathology , diffusing capacity , alternative medicine , physics , optics
Thirty‐four patients with cystic fibrosis (CF) were assessed for baseline pulmonary functions before, and 5 and 15 minutes after cold air challenge (CACh). Most of the patients had no change in forced expiratory volume in 1 second (FEV 1 ) and maximum expiratory flow at 25% vital capacity (Vmax 25%VC ) post‐CACh. Five patients responded with reduced FEV 1 and 13 with reduced Vmax 25%VC . However, paradoxical increases were noted in 10 patients for FEV 1 and in 5 for Vmax 25%VC . Paradoxical responses were most frequent in patients with severe lung disease. The explanation for this variability may lie in the varying degrees of airway instability and volume of airway contribution (VAC) to early flows, resulting from the damage caused by chronic infection. Conventional challenges may be useless in determining the true incidence of bronchial hyperreactivity in patients with CF.