Premium
The functional response of infants with persistent wheezing to nebulized beclomethasone dipropionate
Author(s) -
Maayan C.,
Itzhaki T.,
BarYishay E.,
Gross S.,
Tal A.,
Godfrey S.
Publication year - 1986
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1950020106
Subject(s) - medicine , salbutamol , anesthesia , bronchiolitis , placebo , lung volumes , inhalation , crossover study , plethysmograph , pulmonary function testing , beclometasone dipropionate , bronchodilator , asthma , lung , respiratory system , respiratory disease , alternative medicine , pathology
Lung function was measured in nine infants, ages 15‐36 weeks, who had persistent wheezing, apparently following acute bronchiolitis, before and after 2 weeks of treatment with either inhaled nebulized beclomethasone dipropionate (BDP) or placebo in a randomized, double blind, crossover trial. The effect of nebulized albuterol (Salbutamol) was measured before and after the steroid treatment. Thoracic gas volume (TGV) and specific airway conductance (SG aw ) were determined using a whole body plethysmograph, and forced expiratory flow at resting lung volume (V max FRC) was determined with a thoracoabdominal compression jacket. All infants had marked airways obstruction before treatment with mean ± SE V max FRC of 24 ± 4% predicted and SG aw of 37 ± 5% predicted. Two weeks of placebo treatment had no significant effect on lung function, but after 2 weeks of BDP inhalation there was a significant rise in SG aw to 61 ± 7% (P < 0.005). V max FRC increased to 42 ± 13% but the difference did not reach significance. Respiratory rate and clinical score for retractions and wheezing also fell significantly with BDP therapy (P < 0.01 and P < 0.001 respectively). Albuterol had no effect on lung function either before or during steroid therapy. Steroids may have a role in the management of persistent wheezing following bronchiolitis.