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Bronchiolitis obliterans organizing pneumonia (BOOP) in a child with mild‐to‐moderate asthma: Evidence of mast cell and eosinophil recruitment in lung specimens
Author(s) -
Barbato Angelo,
Panizzolo Cristina,
D'Amore Emanuele S.G.,
La Rosa Mario,
Saetta Marina
Publication year - 2001
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.1064
Subject(s) - medicine , bronchiolitis obliterans , bronchiolitis obliterans organizing pneumonia , bronchiolitis , pathology , lung , pneumonia , granulation tissue , parenchyma , respiratory disease , asthma , eosinophil , bronchoalveolar lavage , biopsy , respiratory system , immunology , wound healing , lung transplantation
Bronchiolitis obliterans with organizing pneumonia (BOOP) is rarely described in children and little is known about its pathogenesis. This paper reports on an 11‐year‐old patient suffering from mild‐to‐moderate asthma. He presented with a retrocardiac density at chest computed tomography scan that was slow to resolve and failed to respond to antibiotic therapy. Open lung biopsy revealed a histological picture with buds of granulation tissue in respiratory bronchioles and alveolar ducts, with organized extensions into the alveoli. The use of monoclonal antibodies on biopsy specimens demonstrated the presence of an inflammatory process affecting not only the thickened alveolar walls, but also the remaining lung parenchyma, the pulmonary arteries, and the bronchioles. The inflammatory infiltrate consisted mainly of mast cells and eosinophils. The clinical condition improved with steroid therapy. To the best of the authors' knowledge, this is the first report of BOOP in an asthmatic child with recruitment of mast cells and eosinophils documented by using monoclonal antibodies. Pediatr Pulmonol. 2001; 31:394–397. © 2001 Wiley‐Liss, Inc.