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Nodular pulmonary vasculitis in a twelve‐year‐old boy
Author(s) -
Borchers T.,
Dirsch O.,
Schaper J.,
Kreuzfelder E.,
Jakob H.,
Ratjen F.
Publication year - 2004
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.10412
Subject(s) - medicine , vasculitis , anti neutrophil cytoplasmic antibody , nodule (geology) , proteinase 3 , pathological , pathology , paleontology , disease , biology
A 12‐year‐old boy presented with left shoulder pain during physical exercise and complained of uncommon sweating and fatigue. Diagnostic evaluation revealed a solitary pulmonary nodule in the left upper lobe. All laboratory values were within normal limits, except for an elevated level of antineutrophil cytoplasmic antibodies directed against myeloperoxidase (p‐ANCA). Surgery was performed, and pathological examination showed a localized granulomatous vasculitis. Antineutrophil cytoplasmic antibodies directed against affinity purified proteinase 3 (p‐ANCA) concentrations returned to baseline within 6 months, and the patient has done well during a follow‐up period of 2 years. While nodular vasculitis is known to occur in Wegener's granulomatosis, to the best of our knowledge, this case represents the first c‐ANCA negative primary pulmonary vasculitis in childhood. Pediatr Pulmonol. 2004; 37:181–185. © 2004 Wiley‐Liss, Inc.