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Lower airway obstruction, bronchial hyperresponsiveness, and primary pulmonary hypertension in children
Author(s) -
Rastogi Deepa,
Ngai Pakkay,
Barst Robyn J.,
Koumbourlis Anastassios C.
Publication year - 2004
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.10363
Subject(s) - medicine , airway obstruction , airway hyperresponsiveness , bronchial hyperresponsiveness , bronchial hyperreactivity , asthma , bronchial obstruction , pulmonary hypertension , airway , cardiology , respiratory disease , anesthesia , lung
We investigated the prevalence and reversibility of lower airway obstruction (LAO) and its correlation with pulmonary artery pressure in children with primary pulmonary hypertension (PPH). The analysis was performed retrospectively in a cohort of children with PPH between 5–18 years of age. PPH was defined as mean pulmonary artery pressure (PAPm) >25 mmHg at rest, or >30 mmHg during exercise, with normal pulmonary capillary wedge pressure in the absence of other causes. Lower airway function was assessed by spirometry and maximal expiratory flow‐volume curves. Lung volumes were measured by body plethysmography. Patients were assigned according to their pattern of lung function into “normal,” “obstructive,” and “restrictive” groups. The reversibility of LAO was defined as an increase of ≥15% from baseline in forced expiratory volume at 1 sec (FEV 1 ) and/or ≥20% in forced expiratory flow at 25–75% of forced vital capacity (FEF 25–75% ) in response to nebulized albuterol. An “obstructive” pattern was found in 23 children (59%), a “restrictive” pattern in 2 children (5%), and a “normal” pattern in 14 children (36%). Response to bronchodilator was documented in 78% of children with an “obstructive” pattern and in 22% of those with a “normal” pattern. The PAPm showed a significant positive correlation with the TLC, RV, and RV/TLC, but a negative one with the ratio FEV 1 /FVC. Our findings suggest that reversible LAO is the most common lung function abnormality among pediatric patients with PPH. Whether airway reactivity is a cause of or the result of PPH remains to be determined. Pediatr Pulmonol. 2004; 37:50–55. © 2004 Wiley‐Liss, Inc.