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Negative expiratory pressure: A new tool for evaluating lung function in children?
Author(s) -
Tauber Erich,
Fazekas Tamas,
Eichler Irmgard,
Eichstill Christina,
Gartner Christian,
Koller Dieter Y.,
Frischer Thomas
Publication year - 2003
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.10233
Subject(s) - medicine , intraclass correlation , asthma , copd , cystic fibrosis , lung volumes , inhalation , reproducibility , salbutamol , pulmonary function testing , population , lung function , cardiology , pediatrics , lung , anesthesia , clinical psychology , statistics , mathematics , environmental health , psychometrics
The negative expiratory pressure technique (NEP) has been applied in adults with chronic obstructive pulmonary disease (COPD), demonstrating flow limitation in many of these patients. Because this technique does not require patient cooperation, it is of potential interest for application in the pediatric population. This study was performed to test the feasibility of NEP in children, and to further investigate it in children with asthma and cystic fibrosis (CF). We performed NEP (0.3–0.7 kPa) measurements in 14 healthy children (13.3 years, ± 2.4), in 12 children with asthma (11.7 years, ± 3.0), and in 17 children with CF (13.3 years, ± 2.7). NEP‐derived flow‐volume loops were visually analyzed for flow limitation at tidal breathing. In addition, expiratory flow at 50% of tidal volume (TEF 50 ) was measured. In healthy children, the intraclass coefficient of correlation was 77%, and intraindividual short‐ and long‐term variability was 5.8% and 10.8%, respectively. In asthmatics, TEF 50 was lower compared with controls, and increased after inhalation of salbutamol. However, appropriate size‐correction has still to be established. Measurement of TEF 50 using NEP is feasible in children. Despite good reproducibility in individual patients, the high intersubject variability may limit its usefulness as a clinical tool. In addition, the lack of flow limitation using NEP even in severely obstructed patients with CF warrants further investigation. Pediatr Pulmonol. 2003; 35:162–168. © 2003 Wiley‐Liss, Inc.