Premium
Improvements of lung function in cystic fibrosis
Author(s) -
Tauber Erich,
Eichler Irmgard,
Gartner Christian,
Halmerbauer Gerhard,
Götz Manfred,
Rath Regina,
Wojnarowski Claudia,
Frischer Thomas
Publication year - 2002
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.10076
Subject(s) - medicine , cystic fibrosis , lung function , pediatrics , lung , pulmonary function testing , respiratory disease , surgery , gastroenterology
Improved care for patients with cystic fibrosis (CF) has led to their improved survival. We analyzed retrospectively whether improvements in lung function (LF) could be detected in our CF patients over the decade 1980–1990. In 72 patients, 153 LF measurements were performed in their first year of life (1980–1991), and then 189 LF measurements were performed again in 60 of those patients during their sixth year of life (1987–1997). Regression analysis was performed on LF parameters at age 6 years. When adjusting for weight, height, gender, and LF in the first year of life, the date of subsequent measurement was positively associated with FEV 1 ( P < 0.01) and MEF 50% ( P < 0.05) and negatively with FRC pleth ( P < 0.05). The proposed model predicts a child's FEV 1 at age 6 to be 75% of predicted if born in 1980, but 108% of predicted when born in 1990. Improved CF care is the most likely explanation for this observation. Pediatr Pulmonol. 2002; 33:263–268. © 2002 Wiley‐Liss, Inc.