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Normal volume of distribution of tobramycin in a mother and daughter with a CFTR splice mutation (1717 − 1G → A)
Author(s) -
Simon Dawn,
Cimino Michael,
Borowitz Drucy
Publication year - 2002
Publication title -
pediatric pulmonology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.866
H-Index - 106
eISSN - 1099-0496
pISSN - 8755-6863
DOI - 10.1002/ppul.10072
Subject(s) - tobramycin , medicine , cystic fibrosis , splice , volume of distribution , mutation , distribution (mathematics) , pharmacokinetics , daughter , genetics , pharmacology , biology , antibiotics , gene , evolutionary biology , mathematical analysis , mathematics , gentamicin
A mother and daughter pair with CF who shared a splice mutation (1717 − 1G → A) had a normal volume of distribution of tobramycin. The literature on tobramycin pharmacokinetics, which was published before the genetic defect was identified, is discussed. The authors speculate on the role of CFTR in the distribution of aminoglycosides and recommend that CFTR mutations should be clarified in all future studies of tobramycin pharmacokinetics in patients with CF. Pediatr Pulmonol. 2002; 33:315‐317. © 2002 Wiley‐Liss, Inc.