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Facile Synthesis of Manganese Tellurite Nanoparticles for Magnetic Resonance Imaging‐Guided Photothermal Therapy
Author(s) -
He Yu,
Guo Yating,
Yu Yanbin,
Luo Peifu,
Qiu Honglong,
Huang Guoming
Publication year - 2021
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202100038
Subject(s) - photothermal therapy , nanoparticle , magnetic resonance imaging , biocompatibility , materials science , nanorod , nanotechnology , in vivo , manganese , nuclear magnetic resonance , medicine , radiology , physics , microbiology and biotechnology , biology , metallurgy
In this study, manganese tellurite (MnTeO 3 ) nanoparticles are developed as theranostic agents for magnetic resonance imaging (MRI)‐guided photothermal therapy of tumor. MnTeO 3 nanoparticles are synthesized via a simple one‐step method. The as‐synthesized MnTeO 3 nanoparticles with uniform size show good biocompatibility. In particular, MnTeO 3 nanoparticles exhibit a high photothermal conversion efficiency (η = 26.3%), which is higher than that of gold nanorods. Moreover, MnTeO 3 nanoparticles also have high MRI performance. The longitudinal relaxivity ( r 1 ) value of MnTeO 3 nanoparticles is determined to be 8.08 ± 0.2 m m −1 s −1 , which is higher than that of clinically approved T 1 ‐contrast agents Gd‐DTPA (4.49 ± 0.1 m m −1 s −1 ). The subsequent MnTeO 3 nanoparticles‐mediated photothermal therapy displays a highly efficient ablation of tumor cells both in vitro and in vivo with negligible toxicity. It is demonstrated that MnTeO 3 nanoparticles can serve as promising theranostic agents with great potentials for MRI‐guided photothermal therapy.