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Zwitterionic‐Functionalized Nanoparticles: Selective Targeting of Lymphoma Cells by Monoclonal Antibody Grafted onto Zwitterionic‐Functionalized Nanoparticles (Part. Part. Syst. Charact. 3/2020)
Author(s) -
Oliveira Jessica Fernanda Affonso,
da Silva Raquel Frenedoso,
Ribeiro Iris Renata Sousa,
Saito Ângela,
MeloHanchuk Talita Diniz,
Dias Marília Meira,
Kobarg Jörg,
Cardoso Mateus Borba
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202070007
Subject(s) - monoclonal antibody , surface modification , nanoparticle , chemistry , transmembrane protein , lymphoma , surface protein , combinatorial chemistry , nanotechnology , biophysics , antibody , biochemistry , virology , biology , materials science , immunology , receptor
In article number 1900446, Mateus Borba Cardoso and co‐workers develop a nanoparticle dual functionalization strategy that allows selective system targetability by minimizing undesirable and non‐specific protein adsorption. These structures are able to selectively interact with L540 lymphocytic cells, likely due to the preferential binding of Ki‐1 mAb grafted on the nanoparticles surface to TNFRSF8 transmembrane protein overexpressed on CD30 + lymphoma cells.