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Contrast‐Enhanced Ultrasound Imaging: Gas‐Generating, pH‐Responsive Calcium Carbonate Hybrid Particles with Biomimetic Coating for Contrast‐Enhanced Ultrasound Imaging (Part. Part. Syst. Charact. 2/2020)
Author(s) -
Vidallon Mark Louis P.,
Douek Alon M.,
Quek Adam,
McLiesh Heather,
Kaslin Jan,
Tabor Rico F.,
Bishop Alexis I.,
Teo Boon Mian
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202070005
Subject(s) - echogenicity , ultrasound , calcium carbonate , coating , bovine serum albumin , chemistry , calcium , contrast (vision) , particle (ecology) , albumin , particle size , ultrasound imaging , membrane , chemical engineering , materials science , biophysics , nanotechnology , chromatography , biochemistry , optics , organic chemistry , radiology , medicine , physics , oceanography , engineering , geology , biology
In article number 1900471, Boon Mian Teo and co‐workers present a polydopamine/bovine serum albumin/calcium carbonate (PDA/BSA/CaCO 3 ) hybrid particle system with a biomimetic red blood cell (RBC) membrane coating. This particle system combines the capability of the RBC membrane to modulate protein corona formation with the pH‐sensitivity of CaCO 3 , producing hyper‐echogenic carbon dioxide bubbles, which are ideal for contrast‐enhanced ultrasound imaging of acidic systems such as tumors.

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