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Biodegradable Black‐Phosphorus‐Nanosheet‐Based Nanoagent for Enhanced Chemo‐Photothermal Therapy
Author(s) -
Xu Xin,
Jiang Yifan,
Wang Min,
Wang Huimeng,
Lu Chunhua,
Yang Huanghao
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202000243
Subject(s) - nanosheet , photothermal therapy , materials science , doxorubicin , plga , nanomedicine , black phosphorus , biodegradation , glycolic acid , nanotechnology , lactic acid , nanoparticle , chemotherapy , chemistry , medicine , bacteria , biology , organic chemistry , optoelectronics , surgery , genetics
Black phosphorus nanosheet (BPNS) is a promising multifunctional material in the biomedical field with biodegradability and low side effects, however its features are always weakened severely owing to its poor stability. Here, a novel method is developed for improving the defect of BPNS based on the effective protection of poly(lactic‐ co ‐glycolic acid) (PLGA), which preserves the stable photothermal therapy (PTT) effect of BPNS and biodegradability of the material. Meanwhile, doxorubicin (DOX) is loaded on BPNS/PLGA to get BPNS/PLGA/DOX for further chemotherapy and preventing the recurrence of tumor after PTT. The presented combined therapeutic strategy exploits the strengths and improves the defects of BPNS, thus developing an efficient and safe nanoagent for cancer therapy, which affords and reveals the great potential of BPNS in nanomedicine.