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Black Phosphorus Nanosheets for Killing Bacteria through Nanoknife Effect
Author(s) -
Guo Tao,
Zhuang Shihao,
Qiu Honglong,
Guo Yating,
Wang Lili,
Jin Guixiao,
Lin Weiwen,
Huang Guoming,
Yang Huanghao
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202000169
Subject(s) - bacteria , antibacterial activity , efflux , staphylococcus aureus , bacterial cell structure , escherichia coli , confocal , chemistry , confocal laser scanning microscopy , microbiology and biotechnology , black phosphorus , rna , scanning electron microscope , biophysics , biology , biochemistry , materials science , physics , optics , genetics , optoelectronics , composite material , gene
Black phosphorus (BP) has emerged as a rapidly rising star in the field of biomedical science. In this work, BP nanosheets (BPNSs) are synthesized and their potential as a nano‐antibacterial agent is investigated. The concentration and time‐dependent antibacterial activities are evaluated by cell viability assays together with scanning electron microscopy, confocal laser scanning microscope, and the measurement of efflux of RNA release assay. The experimental results show that BPNSs have a strong killing effect on both representatives of gram‐negative bacteria ( Escherichia coli ) and gram‐positive bacteria ( Staphylococcus aureus ), and exhibit concentration and time‐dependent antibacterial activity. The sharp edges of BPNSs in the interaction with bacteria can cause physical damage to the bacterial membrane and RNA leakage, resulting in bacterial death. The results demonstrate that the BPNSs show great promise as new nano‐antibacterial materials.