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Porous Lanthanum‐Doped Manganese Oxide Nanoparticles for Enhanced Sonodynamic Cancer Therapy
Author(s) -
Zhou Jinhao,
Shi Liyin,
Liu Qiyu,
Zhang Haozhe,
Liu Xiaoqing,
Han Feng,
Guo Zhixing,
Lu Xihong,
Wang Jianwei
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202000143
Subject(s) - sonodynamic therapy , materials science , nanoparticle , dopant , polyethylene glycol , doping , reactive oxygen species , manganese , yield (engineering) , lanthanum , nanotechnology , chemical engineering , inorganic chemistry , chemistry , metallurgy , organic chemistry , optoelectronics , biochemistry , engineering
Metal oxides hold great promise as robust sonosensitizers for sonodynamic therapy (SDT). However, they usually suffer from limited production yield of reactive oxygen species (ROS) due to the fast recombination of ultrasound‐triggered electrons and holes. Herein, porous lanthanum (La)‐doped MnO 2 (LMO) nanoparticles are firstly developed as promising sonosensitizers in SDT. The strategic introduction of La dopants greatly promotes the separation efficiency of ultrasound‐triggered electrons and holes of MnO 2 , endowing them with significantly improved ROS yield. Consequently, the LMO with polyethylene glycol decoration exhibits good SDT activity toward breast cancer cells. This work highlights the doping strategy for the development of enhanced ROS production of metal oxide sonosensitizers for SDT.