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Combinational Chemotherapy and Photothermal Therapy Using a Gold Nanorod Platform for Cancer Treatment
Author(s) -
Shukla Nutan,
Singh Baljinder,
Kim HoJoong,
Park MyoungHwan,
Kim Kibeom
Publication year - 2020
Publication title -
particle and particle systems characterization
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.877
H-Index - 56
eISSN - 1521-4117
pISSN - 0934-0866
DOI - 10.1002/ppsc.202000099
Subject(s) - photothermal therapy , nanorod , cancer therapy , nanotechnology , cancer treatment , materials science , cancer , chemotherapy , nanomaterials , cancer research , medicine
Abstract Multimodal approaches combined with various nanomaterials and advanced techniques have been developed for synergistic cancer treatment. Among various therapies, conventional chemotherapy (CHT) is a direct cancer treatment that can produce unintended side effects due to nonspecific action on both the tumor and normal cells; patient‐friendly photothermal therapy (PTT) may be able to treat embedded tumors in vital regions with minimal invasion but does not guarantee complete removal of cancers. However, the combination of CHT‐PTT may provide a promising tool for direct cancer treatment with minimal side effects. In this regard, nanostructured materials, such as gold nanorods with tuned size and surface characteristics, are key components designed to enhance the heating capacity and active or passive delivery of drugs to the tumor site. In this review, the pioneering work synergizing CHT and PTT is summarized, and the current state‐of‐the‐art in the development of inorganic and organic nanocomposites for combinational therapy is described.